Avastin 400mg/16 ml infusion vial

Avastin 400mg/16 ml concentrate for intravenous infusion

Avastin by Roche contains bevacizumab, a biological monoclonal antibody that targets vascular endothelial growth factor (VEGF). It helps inhibit the formation of new blood vessels that support tumour growth. Treatment response varies.

What is Avastin used for?

Bevacizumab is used in selected treatment regimens for cancers such as colorectal, certain non-small cell lung, kidney, ovarian, cervical and liver cancers. Eligibility and treatment combinations depend on the specific diagnosis, prior therapy and locally approved product information. It is not suitable for every cancer or every patient.

Product details

• Brand: Avastin.
• Manufacturer: Roche.
• Active ingredient: bevacizumab.
• Total content: 400 mg in 16 ml.
• Concentration: 25 mg/ml.
• Form: concentrate for solution for intravenous infusion.
• Presentation: one vial.

400 mg and 100 mg vial comparison

The 400mg/16 ml vial contains more total medicine than the 100mg/4 ml vial. Both presentations have the same concentration of 25 mg/ml. Vial size does not determine the patient's prescribed dose.

Preparation and administration

The oncology team determines the dose, dilution, treatment interval and infusion rate using the prescribed regimen and manufacturer's instructions. This page describes the intravenous oncology presentation.

Important precautions

Important risks include bleeding, impaired wound healing, high blood pressure, blood clots, gastrointestinal perforation and protein in the urine. Recent or planned surgery, pregnancy, breastfeeding and other treatments require specialist assessment.

Possible side effects

Possible side effects include raised blood pressure, headache, nosebleeds, changes in taste and skin symptoms. Serious complications can occur. Refer to the product leaflet for complete safety information.

Frequently asked questions

Is the 400 mg vial more concentrated than the 100 mg vial?
No. Both contain 25 mg/ml. The 400 mg vial has a larger volume and more total medicine.

Can a bevacizumab biosimilar be substituted directly?
Product choice and switching require confirmation by the treating oncology team. This page does not establish local approval, availability or interchangeability of another brand.

Can hair loss occur during treatment?
Side effects depend on the full treatment regimen, including accompanying chemotherapy. Discuss hair changes with the oncology team.

How should the vial be stored?
Follow the exact storage and handling instructions on the supplied pack and manufacturer's leaflet.

Active ingredient: bevacizumab, 400 mg in 16 ml.